buprenorphine, very long-acting injection improves results of diazepam by Other (see comment). Modify Therapy/watch Closely. remark: Buprenorphine may increase the neuromuscular blocking action of skeletal muscle relaxants and increase hazard for respiratory despair.
drospirenone will increase the degree or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. small/Significance Unknown.
The success of Valium in extensive-expression use, that may be, over 4 months, has not been assessed by systematic clinical scientific tests. The health practitioner must periodically reassess the usefulness on the drug for the individual affected person.
apalutamide will lower the extent or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. steer clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with prescription drugs which have been CYP2C19 substrates can result in reduced publicity to those medicines.
observe for signs of respiratory depression Which might be better than if not envisioned and decrease muscle mass relaxant dosage as vital.
fluconazole will raise the amount or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/keep an eye on.
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just like other brokers that have anticonvulsant exercise, when Valium is used being an adjunct in dealing with convulsive Diseases, the possibility of a rise in the frequency and/or severity of grand mal seizures may possibly involve an increase in the dosage of standard anticonvulsant medication.
zafirlukast will increase the stage or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/observe.
marijuana will raise the degree or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/check.
in several, although not every one of more info these circumstances, buprenorphine was misused by self-injection. If a benzodiazepine have to be utilized for an indication aside from seizures, decreased the benzodiazepine First dose and cautiously titrate to clinical reaction.really serious - Use Alternative (1)buprenorphine subdermal implant and diazepam the two raise sedation. stay clear of or Use Alternate Drug. Restrict use to patients for whom different procedure alternatives are insufficient
lapatinib will enhance the amount or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/observe.
Concomitant usage of benzodiazepines and opioids could bring about profound sedation, respiratory depression, coma, and Demise. Reserve concomitant prescribing of those medicines in sufferers for whom alternate cure choices are insufficient.